Efecto de Ankaferd Blood Stopper sobre el daño cardíaco inducido por cadmio en ratas macho
Resumen
El cadmio (Cd), un contaminante ambiental ampliamente distribuido, es conocido por causar lesiones tisulares a través de mecanismos que implican estrés oxidativo, inflamación y apoptosis. El corazón es particularmente vulnerable a estos efectos tóxicos. Ankaferd Blood Stopper, un agente hemostático herbal estandarizado, también presenta notables actividades antioxidantes, antiinflamatorias y antiapoptóticas. Este estudio tuvo como objetivo explorar los posibles efectos protectores del Ankaferd Blood Stopper frente a la lesión cardíaca inducida por cadmio. Evaluar si la administración de Ankaferd Blood Stopper mitiga el daño histopatológico y apoptótico en el tejido cardíaco causado por la toxicidad por cadmio en ratas. Treinta y dos ratas macho Wistar Albino (350–450 g) se dividieron en cuatro grupos (n=8 cada uno): Control (solución salina, i.p.), Cd (2,5 mg/kg de CdCl₂, i.p.), Ankaferd Blood Stopper (0,5 mL de Ankaferd Blood Stopper, i.p.) y Cd + Ankaferd Blood Stopper (CdCl₂ + Ankaferd Blood Stopper, ambos i.p.). Tras el tratamiento, se recolectaron los tejidos cardíacos y se evaluaron mediante tinción histopatológica e inmunohistoquímica de Caspasa-3. También se obtuvieron muestras de sangre para análisis bioquímico. La exposición al cadmio provocó un daño miocárdico marcado, que incluyó infiltración inflamatoria, congestión vascular y fibras musculares desorganizadas. La expresión de Caspasa-3 confirmó un aumento de la actividad apoptótica. La administración de Ankaferd Blood Stopper redujo significativamente las lesiones histopatológicas y la inmunorreactividad de Caspasa-3 en el grupo Cd + Ankaferd Blood Stopper, lo que sugiere un efecto protector. El Ankaferd Blood Stopper atenuó de forma eficaz la lesión cardíaca inducida por cadmio, probablemente gracias a sus propiedades antioxidantes y antiinflamatorias. Estos hallazgos indican que el Ankaferd Blood Stopper podría ofrecer beneficios terapéuticos para prevenir o aliviar el daño cardiovascular inducido por metales pesados. Se recomienda realizar más investigaciones para validar estos efectos en modelos clínicos y a largo plazo.
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