Efecto protector de los extractos de zumaque y terebinto contra los efectos negativos del cáncer de mama en los tejidos cardíacos de ratas
Resumen
Debido a los efectos secundarios tóxicos de los fármacos quimioterapéuticos utilizados en el cáncer de mama, ha aumentado el interés en las plantas medicinales para desarrollar fármacos alternativos contra el cáncer. El modelo experimental de este estudio se creó para observar los efectos terapéuticos de las plantas de terebinto (Pistacia terebinthus L.) y zumaque (Rhus coriaria L.) contra los efectos negativos del cáncer de mama inducido por 7,12-Dimethylbenz[a] anthracene en el tejido cardíaco de ratas. Para ello, se analizaron los niveles de malondialdehído, indicador del estrés oxidativo que el cáncer de mama causa en el tejido cardíaco; las enzimas catalasa, glutatión transferasa y superóxido dismutasa; y el glutatión, que desempeña un papel importante entre los antioxidantes y las proteínas. Al finalizar el estudio, se observó un aumento en el nivel de malondialdehído, una disminución en los niveles de glutatión y proteínas en las ratas con 7,12-Dimethylbenz[a] anthracene inducido por cáncer, y una disminución en los niveles de enzimas antioxidantes.
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Sheokand S, Navik U, Bansal AK. Nanocrystalline solid dispersions (NSD) of hesperetin (HRN) for prevention of 7, 12-dimethylbenz [a] anthracene (DMBA)-induced breast cancer in Sprague-Dawley (SD) rats. Eur. J. Pharm. Sci. [Internet]. 2019; 128:240-249. doi: https://doi.org/qb78 DOI: https://doi.org/10.1016/j.ejps.2018.12.006
McGowan JV, Chung R, Maulik A, Piotrowska I, MalcolmWalker J, Yellon DM. Anthracycline chemotherapy and cardiotoxicity. Cardiovasc. Drugs Ther. [Internet]. 2019; 31 (1): 63–75. doi: https://doi.org/f9xtdv DOI: https://doi.org/10.1007/s10557-016-6711-0
Jeyaprakash P, Sangha S, Ellenberger K, Sivapathan S, Pathan F, Negishi K. Cardiotoxic effect of modern anthracycline dosing on left ventricular ejection fraction: a systematic review and meta-analysis of placebo arms from randomized controlled trials. J. Am. Heart Assoc. [Internet]. 2021; 10(6):e018802. doi: https://doi.org/grcdwx DOI: https://doi.org/10.1161/JAHA.120.018802
Torti FM, Bristow MR, Howes AE, Aston D, Stockdale FE, Carter SK, KOHLER M, BROWN Jr. BW, BILLINGHAM ME. Reduced cardiotoxicity of doxorubicin delivered on a weekly schedule: Assessment by endomyocardial biopsy. Ann. Intern. Med. [Internet]. 1983; 99(6):745–749. doi: https://doi.org/qb79 DOI: https://doi.org/10.7326/0003-4819-99-6-745
Topçu G, Ay M, Bilici A, Sarıkürkcü C, Öztürk M, Ulubelen A. A new flavone from antioxidant extracts of Pistacia terebinthus. Food Chem. [Internet]. 2007; 103(3):816-822. doi: https://doi.org/cbfc3g DOI: https://doi.org/10.1016/j.foodchem.2006.09.028
Germano MP, Pasqualo RD, D’Angelo V, Catania S, Silvari V, Costa C. Evaluation of Extracts and Isolated Fraction from Capparis spinosa L. Buds as an Antioxidant Source. J. Agric. Food Chem. [Internet]. 2002; 50(5):1168-1171. doi: https://doi.org/ffwkb3 DOI: https://doi.org/10.1021/jf010678d
Shabbir A. Rhus coriaria linn, a plant of medicinal, nutritional and industrial importance: A review. J. Anim. Plant. Sci. [Internet]. 2012 [cited 22 Jun 2025]; 22(2):505-512. Available in: https://goo.su/5SsMVUf
Mizushima N, Levine B. Autophagy in mammalian development and differentiation. Nat. Cell Biol. [Internet]. 2010; 12:823-830. doi: https://doi.org/cvnkcz DOI: https://doi.org/10.1038/ncb0910-823
Zargham H, Zargham R. Tannin extracted from Sumac inhibits vascular smooth muscle cell migration. Mcgill. J. Med. [Internet]. 2008 [cited 14 Jun 2025]; 11(2):119–123. Available in: https://goo.su/k7oMA DOI: https://doi.org/10.26443/mjm.v11i2.601
Anwer T, Sharma M, Khan G, Iqbal M, Ali MS, Alam MS, Safhi MM, Gupta N. Rhus coriaria ameliorates insulin resistance in non-insulin-dependent diabetes mellitus (NIDDM) rats. Acta Pol. Pharm. [Internet]. 2013 [cited 02 May 2025]; 70(5):861-867. Available in: https://goo.su/m2yIU9
Panico A, Cardile V, Santagati NA, Messina R. Antioxidant and protective effects of Sumac Leaves on Chondrocytes. J. Med. Plants Res. [Internet]. 2009 [cited 15 Jun 2025]; 3(11):855–861. Available in: https://goo.su/71x5EJ
Pourahmad J, Eskandari, MR, Shakibaei R, Kamalinejad M. A search for hepatoprotective activity of aqueous extract of Rhus coriaria L. against oxidative stress cytotoxicity. Food Chem. Toxicol. [Internet]. 2010; 48(3):854-858. doi: https://doi.org/d2q4ff DOI: https://doi.org/10.1016/j.fct.2009.12.021
Chakraborty A., Ferk F, Simic T, Brantner A, Dušinská M, Kundi M, Hoelzl C, Nersesyan A, Knasmüller S. DNAprotective effects of sumach (Rhus coriaria L.), a common spice: results of human and animal studies. Mutat. Res. Fund. Mol. Mech. Mutagen. [Internet]. 2009; 661(12): 10-17. doi: https://doi.org/ftn2tn DOI: https://doi.org/10.1016/j.mrfmmm.2008.10.009
Hasasna H, Athamneh K, Al Samri H, Karuvantevida N, Al Dhaheri Y, Hisaindee S, Ramadan G, Al Tamimi N, AbuQamar S, Eid A, Iratni R. Rhus coriaria induces senescence and autophagic cell death in breast cancer cells through a mechanism involving p38 and ERK1/2 activation. Sci. Rep. [Internet]. 2015; 5: 13013. doi: https://doi.org/f7mj5z DOI: https://doi.org/10.1038/srep13013
El Hasasna H, Saleh A, Al Samri H, Athamneh K, Attoub S, Arafat K, Benhalilou N, Alyan S, Viallet J, Al Dhaheri Y, Eid A, Iratni R. Rhus coriaria suppresses angiogenesis, metastasis and tumor growth of breast cancer through inhibition of STAT3, NF.B and nitric oxide pathways. Sci. Rep. [Internet]. 2016; 6:21144. doi: https://doi.org/qb8b DOI: https://doi.org/10.1038/srep21144
Davis PH, Cullen J, Coode MJE. Polygonaceae. Flora of Turkey and the East Aegean Islands, 2 nd ed. Edinburgh: Edinburgh University Press; 1967.
Mundhe NA, Kumar P, Ahmed S, Jamdade V, Mundhe S, Lahkar M. Nordihydroguaiaretic acid ameliorates cisplatin induced nephrotoxicity and potentiates its anti-tumor activity in DMBA induced breast cancer in female Sprague–Dawley rats. Int. Immunopharmacol. [Internet]. 2015; 28(1):634–642. doi: https://doi.org/f7rvfb DOI: https://doi.org/10.1016/j.intimp.2015.07.016
Demir E, Yilmaz Ö. The Effect of Bitter Almond Oil on The Some Alterations in Liver Tissue of Experimental Diabetic Rats. Van Vet. J. [Internet]. 2015 [cited 15 Jun 2025]; 26(1):17-23. Available in: https://goo.su/JvGKDX
Lowry OH, Rosenbrough NJ, Farr AL, Randall RJ. Protein measurement with the Folin-phenol reagent. J. Biol. Chem. [Internet]. 1951 [cited 15 Jun 2025]; 193(1):265275. Available in: https://goo.su/kwZeb31 DOI: https://doi.org/10.1016/S0021-9258(19)52451-6
Ohkawa H, Ohishi N, Yagi K. Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction. Anal. Biochem. [Internet]. 1979; 95(2):351–358. doi: https://doi.org/bktx4x DOI: https://doi.org/10.1016/0003-2697(79)90738-3
Elman GI. Tissue Sulfhydryl Groups. Arch. Biochem. Biophys. [Internet]. 1959; 82(1):70-77. doi: https://doi.org/bz2vt8 DOI: https://doi.org/10.1016/0003-9861(59)90090-6
Pinho RA, Andrades ME, Oliveira MR, Pirola AC, Zago MS, Silveira PC, Dal-Pizzol F, Moreira JCF. Imbalance in SOD/CAT activities in rat skeletal muscles submitted to treadmill training exercise. Cell Biol. Int. [Internet]. 2006; 30(10):848-853. doi: https://doi.org/c66kdh DOI: https://doi.org/10.1016/j.cellbi.2006.03.011
Aebi, H. Catalase Invitro. Meth. Enzymol. [Internet]. 1984; 105:121-126. doi: https://doi.org/dnf7v9 DOI: https://doi.org/10.1016/S0076-6879(84)05016-3
Bell JG, Cowey CB, Adron JW, Shanks AM. Some effects of vitamin E and selenium deprivation on tissue enzyme levels and indices of tissue peroxidation in rainbow trout (Salmo gairdneri). Br. J. Nutr. [Internet]. 1985; 53:149–157. doi: https://doi.org/fmnrbk DOI: https://doi.org/10.1079/BJN19850019
Dong X, Yang Y, Zhou Y, Bi X, Zhao N, Zhang Zet, Li L, Hang Q, Zhang R, Chen D, Cao P, Yin Z, Luo L. Glutathione S-transferases P1 protects breast cancer cell from adriamycin-induced cell death through promoting autophagy. Cell Death Differ. [Internet]. 2019; 26:20862099. doi: https://doi.org/qb8k DOI: https://doi.org/10.1038/s41418-019-0276-y
Kavak D, Altiok E, Bayraktar O, Ülkü S. Pistacia terebinthus extract: As a potential antioxidant, antimicrobial and possible ß- glucuronidase inhibitor. J. Mol. Catal. B. Enzym. [Internet]. 2010; 64(3-4):167-171. doi: https://doi.org/fgcckh DOI: https://doi.org/10.1016/j.molcatb.2010.01.029
Lee EJ, Oh SY, Sung MK. Luteolin exerts anti-tumor activity through the suppression of epidermal growth factor receptor-mediated pathway in MDA-MB-231 ER-negative breast cancer cells. Food Chem. Toxicol. [Internet]. 2012; 50(11):4136-4143. doi: https://doi.org/f39z23 DOI: https://doi.org/10.1016/j.fct.2012.08.025
Hamdy SM, Sayed O, Latif AKMA, Abdel-Aziz AM, Amin AM. Hesperidin and tiger nut reduced carcinogenicity of DMBA in female rats. Biomed. Pharmacother. [Internet]. 2016; 83:718-724. doi: https://doi.org/qb8n DOI: https://doi.org/10.1016/j.biopha.2016.07.032
Karnam KC, Ellutla M, Bodduluru LN, Kasala ER, UppulapuSK, Kalyankumarraju M, Lahkar M. Preventive effect of berberine against DMBA-induced breast cancer in female Sprague Dawley rats. Biomed. Pharmacother. [Internet]. 2017; 92:207-214. doi: https://doi.org/gbtzg3 DOI: https://doi.org/10.1016/j.biopha.2017.05.069
Ramírez-Expósito MJ, Urbano-Polo N, Dueñas B, Navarro-Cecilia J, Ramírez-Tortosa C, Martín-Salvago MD, Martínez-Martos JM. Redox status in the sentinel lymph node of women with breast cancer. Upsala J. Med. Sci. [Internet]. 2017; 122(4):207-216. doi: https://doi.org/qb8p DOI: https://doi.org/10.1080/03009734.2017.1403522
Beutler E. Nutritional and metabolic aspects of glutathione. Annu. Rev. Nutr. [Internet]. 1989; 9:287–302. doi: https://doi.org/fhz9sk DOI: https://doi.org/10.1146/annurev.nu.09.070189.001443
Coughlin SS. Oxidative Stress, Antioxidants, Physical Activity, and the Prevention of Breast Cancer Initiation and Progression. J. Environ. Health Sci. [Internet]. 2018 [cited 15 Jun 2025]; 4(2):55-57. Available in: https://goo.su/iD0dEk
Kadam CY, Abhang SA. Evaluation of serum levels of reduced glutathione, glutathione-stransferase and nitric oxide in breast cancer patients undergoing adjuvant chemotherapy. Int. J. Cur. Res. Rev. 2013 [cited 15 Jun 2025]; 5(13):51-57. Available in: https://goo.su/nS7Oq
