Chronic fatigue, myalgic encephalomyelitis/chronic fatigue syndrome and SARS-CoV-2
La fatiga crónica, la encefalomielitis miálgica/síndrome de fatiga crónica y el SARS-CoV-2.
Abstract
Chronic fatigue can be observed as an isolated complaint, coexist with several neuro-psychiatric and chronic pain disorders, or be reported as the main symptom of the complex known as myalgic encephalomyelitis/chronic fatigue syndrome. This is a clinically heteroge-neous, multisystem disease, characterized by severe fatigue, cognitive impairment, sleep dis-turbances, and autonomic and gastrointestinal perturbations. Several viral epidemics have been related with increases in complaints of chronic fatigue and the diagnosis of myalgic en-cephalomyelitis/chronic fatigue syndrome, in convalescent patients. Alterations in distinct organ systems, including exacerbations of the immune-inflammatory response, seem to play important roles in the pathophysiology of the disorder. In this regard, the elevated transmis-sibility of the SARS-CoV-2 and the strong inflammatory response of the host, triggered by the virus, could potentially lead to a significant increase in the manifestation of chronic fa-tigue as a symptom and in the number of cases of myalgic encephalomyelitis/chronic fatigue syndrome. Early vigilance and detection will allow for the timely diagnosis and the proper therapeutic approach.
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References
Williams FMK, Muirhead N, Pariante C. Covid-19 and chronic fatigue. BMJ 2020; 370:m2922. doi: 10.1136/bmj.m2922.
Morris G, Maes M, Berk M, Puri BK. Myalgic encephalomyelitis or chronic fatigue syndrome: how could the illness develop? Metab Brain Dis 2019; 34:385–415.
Islam MF, Cotler J, Jason LA. Post-viral fatigue and COVID-19: lessons from past epidemics. Fatigue 2020, 8(2): 61–69. doi: https://doi.org/10.1080/21641846.2020.1778227.
Mohabbat AB, Mohabbat NML, Wight EC. Fibromyalgia and chronic fatigue syndrome in the age of COVID-19. Mayo Clin Proc Inn Qual Out 2020; 4(6):764-766. doi: https://doi.org/10.1016/j. mayocpiqo.2020.08.002.
Yang T, Yang Y, Wang D, Li C, Qu Y, Guo J, Shi T, Bo W, Sun Z, Asakawa T. The clinical value of cytokines in chronic fatigue syndrome. J Transl Med 2019; 17(1):213. doi: https://doi.org/10.1186/ s12967-019-1948-6.
Missailidis D, Annesley SJ, Fisher PR. Pathological mechanisms underlying myalgic encephalomyelitis/chronic fatigue syndrome. Diagnostics (Basel) 2019, 9(3): 80. doi:10.3390/diagnostics9030080.
Song P, Li W, Xie J, Hou Y, You C. Cytokine storm induced by SARS-CoV-2. Clin Chim Acta 2020; 509: 280–287.
Koralnik IJ, Tyler KL. COVID-19: a global threat to the nervous system. Ann Neurol 2020; 88:1–11.
