Modulation of catastrophic thinking, pain and inflammation in fibromyalgia: from behavior to molecular biology.
Modulación del pensamiento catastrófico, dolor e inflamación en fibromialgia. Del comportamiento a la biología molecular.
Keywords:
fibromyalgia, cognitive behavioral intervention, IL -6, cortisol, psychophysiological intervention, catastrophic thinking
Abstract
Fibromyalgia (FM) is a disease characterized by chronic pain (CP), stress, and cognitive alterations. Catastrophic thinking (CT) is mediated by cortisol, IL -6, and the serotonin receptor 5HT1A (5HT1A). The study’s ob-jective was to identify whether the modification of CT affects these biological variables, comparing a cognitive behavioral intervention (CBI) and a psycho-physiological intervention (PPI) in women with FM. The duration of both inter-ventions was 11 weeks. It was a non-probabilistic, comparative, experimental, and clinical study. Forty-eight women of the Rheumatology Service of the Gen-eral Hospital of Mexico participated. Health Assessment Questionnaire (HAQ-DI), Catastrophizing Scale for Fibromyalgia (PCS), and Perceived Stress Scale (PSS) were administered. The relative expression of IL -6 and serotonin receptor (5HT1A) genes were quantified by real-time PCR; likewise, IL -6 and cortisol lev-els were measured in serum. The ICC showed significant changes in perception of stress (p = 0.05), in PC in the rumination scales (p = 0.05), magnification (p = 0.01), hopelessness (p = 0.01), cortisol (p = 0.01) and IL -6 (p = 0.01). Pain scores (p = 0.01) improved in both groups. The IPF showed an increase in the relative expression of the gene that codes for the serotonin receptor 5HT1A (p = 0.05). IL -6 was found to be a predictor of rumination thinking in the ICC group. The results allow us to conclude that ICC had a greater impact on CP, stress, IL -6 and cortisol, compared to the PPI.
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References
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Barceló Martinez E, Gelves Ospina M, Navarro Lechuga E, Allegri RF, Orozco Acosta E, Benitez Agudelo JC, León Jacobus A, Román NF. Serum cortisol levels and neuropsychological impairments in patients diagnosed with fibromyalgia. Actas Españolas Psiquiatr 2018;46(1):1–11.
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Sturgeon JA, Zautra AJ. State and trait pain catastrophizing and emotional health in rheumatoid arthritis. Ann Behav Med 2014;45(1):69–77.
Lazaridou A, Martel MO, Cahalan CM, Franceschelli O, Campbell CM, Haythornthwaite JA, Smith M, Riley J, Edwards RR. The impact of anxiety and catastrophizing on interleukin-6 responses to acute painful stress. J Pain Res 2018;11:637–647.
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Morris LD, Louw QA, Grimmer KA, Meintjes E. Targeting pain catastrophization in patients with fibromyalgia using virtual reality exposure therapy : a proof-of-concept study. J Phys Ther Sci 2015;27:3461–3467.
Sharma S, Thibault P, Abbott JH, Jensen MP. Clinimetric properties of the Nepali version of the Pain Catastrophizing Scale in individuals with chronic pain. J Pain Res 2018;11:265–276.
Clauw DJ. Fibromyalgia. A clinical review. JAMA 2014;311(15):1547–1555.
Geiss A, Rohleder N, Anton F. Evidence for an association between an enhanced reactivity of interleukin-6 levels and reduced glucocorticoid sensitivity in patients with fibromyalgia. Psychoneuroendocrino logy 2012;37(5):671–684. Available from: http://dx.doi.org/10.1016/j.psyneuen. 2011.07.021.
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Leung L. Pain catastrophizing : an updated review. Indian J Psychol Med 2012; 34(3):204–217.
Shivers KY, Amador N, Abrams L, Hunter D, Jenab S, Quiñones Jenab V. Estrogen alters baseline and inflammatory induced cytokine levels independent from hypothalamic pituitary adrenal axis activity. Cytokine 2015;72(2):121–129.
Park DJ, Kang JH, Yim YR, Kim JE, Lee JW, Lee KE, Wen L, Kim TJ, Park YW, Lee SS. Exploring genetic susceptibility to fibromyalgia. Chonnam Med J 2015;51(2):58-65.
Kosek E, Martinsen S, Gerdle B, Manerkorpi K, Löfgren M, Bileviciute ljungar I, Fransson P, Schalling M, Ingvar M, Emberg M, Jensen KB. The translocator protein gene is associated with symptom severity and cerebral pain processing in fibromyalgia. Brain Behav Immun 2016;58:218-227. Available from: http:// dx.doi.org/10.1016/j.bbi.2016.07.150.
Köllner V, Häuser W, Klimczyk K, Kühn Becker H, Settan M, Weigl M, Bernardy K. Psychotherapie von patienten mit fibromyal giesyndrom. Schmerz 2012;26:291–296.
Lami MJ, Martínez MP, Sánchez AI. Systematic review of psychological treatment in fibromyalgia. Curr Pain Headache Rep 2013;17(7):345-358.
Glasgow A, Stone TM, Kingsley JD. Resistance rxercise training on disease impact, pain catastrophizing and autonomic modulation in women with fibromyalgia. Int Journal Exerc Sci 2017;10(8):1184–1195.
Schmidt JE, Brien TGO, Hooten WM, Joyner MJ, Johnson BD. The effects of slow paced versus mechanically assisted breathing on autonomic function in fibromyalgia patients. J Pain Res 2017;10:2761–2768.
Häuser W, Ablin J, Perrot S, Fitzcharles MA. Management of fibromyalgia: key messages from recent evidence based guidelines. Polish Arch Intern Med 2017;127(1):47–56.
Thieme K, Mathys M, Turk DC. Evidenced based guidelines on the treatment of fibromyalgia patients: are they consistent and if not, why not? Have effective psychological treatments been overlooked? J Pain 2017;18(7):747–756. Available from: http:// dx.doi.org/10.1016/j.jpain.2016.12.006
Giusti EM, Castelnuovo G, Molinari E. Differences in multidisciplinary and interdisciplinary treatment programs for fibromyalgia: a mapping review. Pain Res Manag 2017;2017:7261468. doi: 10. 1155/2017/7261468.
Lumley MA, Schubiner H, Lockhart NA, Kidwell KM, Harte SE, Clauw DJ, Williams DA. Emotional awareness and expression therapy, cognitive behavioral therapy, and education for fibromyalgia: a cluster randomized controlled trial. Pain 2017;158(12):2354–2363.
McCrae CS, Williams J, Roditi D, Anderson R, Mundt JM, Miller MB, Curtis AF, Waxenberg LB, Staud R, Berry RB, Robinson ME. Cognitive behavioral treatments for insomnia and pain in adults with comorbid chronic insomnia and fibromyalgia: clinical outcomes from the SPIN randomized controlled trial. Sleep 2019;42(3):1–15.
Porges SW. The polyvagal perspective. Biol Psychol 2007;74(2):116–143.
Meeus M, Nijs J, Hermans L, Goubert D, Calders P. The role of mitochondrial dysfunctions due to oxidative and nitrosative stress in the chronic pain or chronic fatigue syndromes and fibromyalgia patients: Peripheral and central mechanisms as therapeutic targets? Expert Opin Ther Targets 2013;17(9):1081–1089.
Kang JH, Kim JK, Hong SH, Lee CH, Choi BY. Heart rate variability for quantification of autonomic dysfunction in fibromyalgia. Ann Rehabil Med 2016;40(2):301–309.
Garrido M, Castaño MY, Biehl Printes C, Gomez MA, Branco JC, Tomas Carus P, Rodriguez AB. Effects of a respiratory functional training program on pain and sleep quality in patients with fibromyalgia: A pilot study. Complement Ther Clin Pract 2017;28:116–121. Available from: http:// dx.doi.org/10.1016/j.ctcp.2017.05.013
Jafari H, Courtois I, Van Den Bergh O, Vlaeyen JWS, Van Diest I. Pain and respiration: A systematic review. Pain 2017;158(6):995– 1006.
Katzman M, Vermani M, Gerbarg PL, Brown RP, Iorio C, Davis M, Cameron C, Tsirgielis D. A multicomponent yoga based, breath intervention program as an adjunctive treatment in patients suffering from generalized anxiety disorder with or without comorbidities. Int J Yoga 2012;5(1):57-65. Available from: http:// www.ijoy.org.in/text.asp? 2012/5/1/57/ 91716
Busch V, Magerl W, Kern U, Haas J, Hajak G, Eichhammer P. The effect of deep and slow breathing on pain perception , autonomic activity , and mood processing — An experimental Study. Pain Med (United States) 2012;13:215–228.
Tomas Carus P, Garrido M, Branco JC, Castaño MY, Gómez MÁ, Biehl Printes C. Non supervised breathing exercise regimen in women with fibromyalgia: A quasi-experimental exploratory study. Complement Ther Clin Pract 2019;35:170–176. Available from: https://doi.org/10.1016/j. ctcp.2019.02.006
Kuribayashi T. Elimination half-lives of interleukin-6 and cytokine-induced neutrophil chemoattractant-1 synthesized in response to inflammatory stimulation in rats. Lab Anim Res 2018: 34(2), 80-83. Available from: https://doi.org/10.5625/ lar.2018.34.2.80.
Vachon Presseau E, Martel MO, Roy M, Caron E, Albouy G, Marin MF, Plante I, Sullivan MJ, Lupien SJ, Rainville P. Acute stress contributes to individual differences in pain and pain related brain activity in healthy and chronic pain patients. J Neurosci 2013;33(16):6826–6833.
Iwabe T, Ozaki I, Hashizume A. The respiratory cycle modulates brain potentials, sympathetic activity , and subjective pain sensation induced by noxious stimulation. Neurosci Res 2014;84:47–59. Available from: http://dx.doi.org/10.1016/j.neures. 2014.03.003
Steinberg LJ, Rubin Falcone H, Galfalvy HC, Kaufman J, Miller JM, Sublette ME, Cooper TB, Min E, Keilp JG, Stanley BH, Oquenda MA, Ogden RT, Mann JJ. Cortisol stress response and in vivo pet imaging of human brain serotonin 1a receptor binding. Int J Neuropsychopharmacol 2019;22(5):329–338.
Badawy AA, Morgan CJ, Lovett JW, Bradley DM, Thomas R. Decrease in circulating tryptophan availability to the brain after acute ethanol consumption by normal volunteers: implications for alcohol-induced aggressive behaviour and depression. Pharmacopsychiatry 1995;28:93–97.
Úbeda D’Ocasar E, Jiménez Díaz Benito V, Gallego Sendarrubias GM, Valero Calero JA, Vicario Merino JA, Vicario Merino A, Hervás Pérez JP. Pain and cortisol in patients with fibromyalgia: systematic review and meta-analysis. Diagnostics (Basel) 2020;10(11):922. doi: 10.3390/diagnostics10110922.
Barrera Villalpando MI, Cortes Sotres JF, Mendieta Cabrera D, Guerrero León D. Reduction of the parasympathetic influx in fibromyalgia: Its relationship with psychiatry in a national referral specialized center. Salud Ment 2015;38(2):123–128.
Behm FG, Gavin IM, Karpenko O, Lindgren V, Gaitonde S, Gashkoff PA, Gillis BS. Unique immunologic patterns in fibromyalgia. BMC Clin Pathol 2012;12(25):1–7.
Kosek E, Altawil R, Kadetoff D, Finn A, Westman M, Le Maître E, Andersson M, Jensen Urstad M, Lampa J. Evidence of different mediators of central inflammation in dysfunctional and inflammatory pain-interleukin-8 in fibromyalgia and interleukin-1 β in rheumatoid arthritis. J Neuroim munol 2015;280:49–55.
Mendieta D, Luz D, Cruz Aguilera D, Barrera Villalpando MI, Becerril Villanueva E, Arreola R, Hernández Ferreira E, Pérez Tapia SM, Pérez Sánchez G, Garcés Alvarez ME, Aguirre Cruz L, Velasco Velázquez MA, Pavón L. IL -8 and IL -6 primarily mediate the inflammatory response in fibromyalgia patients. J Neuroim- munol 2016;290:22–25. Available from: http://dx.doi.org/10.1016/j.jneuroim. 2015.11.011
Hannibal KE, Bishop MD. Chronic stress, cortisol dysfunction , and pain : A psycho neuroendocrine rationale for stress management in pain rehabilitation. Phys Ther 2014;94:1816–1825.
Barceló Martinez E, Gelves Ospina M, Navarro Lechuga E, Allegri RF, Orozco Acosta E, Benitez Agudelo JC, León Jacobus A, Román NF. Serum cortisol levels and neuropsychological impairments in patients diagnosed with fibromyalgia. Actas Españolas Psiquiatr 2018;46(1):1–11.
Taylor AG, Adelstein KE, Fischer White TG, Murugesan M, Anderson JG. Perspectives on living with fibromyalgia. Glob Qual Nurs Res 2016;3:1–13.
Sturgeon JA, Zautra AJ. State and trait pain catastrophizing and emotional health in rheumatoid arthritis. Ann Behav Med 2014;45(1):69–77.
Lazaridou A, Martel MO, Cahalan CM, Franceschelli O, Campbell CM, Haythornthwaite JA, Smith M, Riley J, Edwards RR. The impact of anxiety and catastrophizing on interleukin-6 responses to acute painful stress. J Pain Res 2018;11:637–647.
Burri A, Ogata S, Rice D, Williams F. Pain catastrophizing, neuroticism , fear of pain, and anxiety: defining the genetic and environmental factors in a sample of female twins. PLoS One 2018;13(3):1–15.
Morris LD, Louw QA, Grimmer KA, Meintjes E. Targeting pain catastrophization in patients with fibromyalgia using virtual reality exposure therapy : a proof-of-concept study. J Phys Ther Sci 2015;27:3461–3467.
Sharma S, Thibault P, Abbott JH, Jensen MP. Clinimetric properties of the Nepali version of the Pain Catastrophizing Scale in individuals with chronic pain. J Pain Res 2018;11:265–276.
Clauw DJ. Fibromyalgia. A clinical review. JAMA 2014;311(15):1547–1555.
Geiss A, Rohleder N, Anton F. Evidence for an association between an enhanced reactivity of interleukin-6 levels and reduced glucocorticoid sensitivity in patients with fibromyalgia. Psychoneuroendocrino logy 2012;37(5):671–684. Available from: http://dx.doi.org/10.1016/j.psyneuen. 2011.07.021.
Rodriguez Pintó I, Agmon levin N, Howard A, Shoenfeld Y. Fibromyalgia and cytokines. Immunol Lett 2014;161(2):200-203. Available from: http://dx.doi.org/10.1016/j. imlet.2014.01.009.
Leung L. Pain catastrophizing : an updated review. Indian J Psychol Med 2012; 34(3):204–217.
Shivers KY, Amador N, Abrams L, Hunter D, Jenab S, Quiñones Jenab V. Estrogen alters baseline and inflammatory induced cytokine levels independent from hypothalamic pituitary adrenal axis activity. Cytokine 2015;72(2):121–129.
Park DJ, Kang JH, Yim YR, Kim JE, Lee JW, Lee KE, Wen L, Kim TJ, Park YW, Lee SS. Exploring genetic susceptibility to fibromyalgia. Chonnam Med J 2015;51(2):58-65.
Kosek E, Martinsen S, Gerdle B, Manerkorpi K, Löfgren M, Bileviciute ljungar I, Fransson P, Schalling M, Ingvar M, Emberg M, Jensen KB. The translocator protein gene is associated with symptom severity and cerebral pain processing in fibromyalgia. Brain Behav Immun 2016;58:218-227. Available from: http:// dx.doi.org/10.1016/j.bbi.2016.07.150.
Köllner V, Häuser W, Klimczyk K, Kühn Becker H, Settan M, Weigl M, Bernardy K. Psychotherapie von patienten mit fibromyal giesyndrom. Schmerz 2012;26:291–296.
Lami MJ, Martínez MP, Sánchez AI. Systematic review of psychological treatment in fibromyalgia. Curr Pain Headache Rep 2013;17(7):345-358.
Glasgow A, Stone TM, Kingsley JD. Resistance rxercise training on disease impact, pain catastrophizing and autonomic modulation in women with fibromyalgia. Int Journal Exerc Sci 2017;10(8):1184–1195.
Schmidt JE, Brien TGO, Hooten WM, Joyner MJ, Johnson BD. The effects of slow paced versus mechanically assisted breathing on autonomic function in fibromyalgia patients. J Pain Res 2017;10:2761–2768.
Häuser W, Ablin J, Perrot S, Fitzcharles MA. Management of fibromyalgia: key messages from recent evidence based guidelines. Polish Arch Intern Med 2017;127(1):47–56.
Thieme K, Mathys M, Turk DC. Evidenced based guidelines on the treatment of fibromyalgia patients: are they consistent and if not, why not? Have effective psychological treatments been overlooked? J Pain 2017;18(7):747–756. Available from: http:// dx.doi.org/10.1016/j.jpain.2016.12.006
Giusti EM, Castelnuovo G, Molinari E. Differences in multidisciplinary and interdisciplinary treatment programs for fibromyalgia: a mapping review. Pain Res Manag 2017;2017:7261468. doi: 10. 1155/2017/7261468.
Lumley MA, Schubiner H, Lockhart NA, Kidwell KM, Harte SE, Clauw DJ, Williams DA. Emotional awareness and expression therapy, cognitive behavioral therapy, and education for fibromyalgia: a cluster randomized controlled trial. Pain 2017;158(12):2354–2363.
McCrae CS, Williams J, Roditi D, Anderson R, Mundt JM, Miller MB, Curtis AF, Waxenberg LB, Staud R, Berry RB, Robinson ME. Cognitive behavioral treatments for insomnia and pain in adults with comorbid chronic insomnia and fibromyalgia: clinical outcomes from the SPIN randomized controlled trial. Sleep 2019;42(3):1–15.
Porges SW. The polyvagal perspective. Biol Psychol 2007;74(2):116–143.
Meeus M, Nijs J, Hermans L, Goubert D, Calders P. The role of mitochondrial dysfunctions due to oxidative and nitrosative stress in the chronic pain or chronic fatigue syndromes and fibromyalgia patients: Peripheral and central mechanisms as therapeutic targets? Expert Opin Ther Targets 2013;17(9):1081–1089.
Kang JH, Kim JK, Hong SH, Lee CH, Choi BY. Heart rate variability for quantification of autonomic dysfunction in fibromyalgia. Ann Rehabil Med 2016;40(2):301–309.
Garrido M, Castaño MY, Biehl Printes C, Gomez MA, Branco JC, Tomas Carus P, Rodriguez AB. Effects of a respiratory functional training program on pain and sleep quality in patients with fibromyalgia: A pilot study. Complement Ther Clin Pract 2017;28:116–121. Available from: http:// dx.doi.org/10.1016/j.ctcp.2017.05.013
Jafari H, Courtois I, Van Den Bergh O, Vlaeyen JWS, Van Diest I. Pain and respiration: A systematic review. Pain 2017;158(6):995– 1006.
Katzman M, Vermani M, Gerbarg PL, Brown RP, Iorio C, Davis M, Cameron C, Tsirgielis D. A multicomponent yoga based, breath intervention program as an adjunctive treatment in patients suffering from generalized anxiety disorder with or without comorbidities. Int J Yoga 2012;5(1):57-65. Available from: http:// www.ijoy.org.in/text.asp? 2012/5/1/57/ 91716
Busch V, Magerl W, Kern U, Haas J, Hajak G, Eichhammer P. The effect of deep and slow breathing on pain perception , autonomic activity , and mood processing — An experimental Study. Pain Med (United States) 2012;13:215–228.
Tomas Carus P, Garrido M, Branco JC, Castaño MY, Gómez MÁ, Biehl Printes C. Non supervised breathing exercise regimen in women with fibromyalgia: A quasi-experimental exploratory study. Complement Ther Clin Pract 2019;35:170–176. Available from: https://doi.org/10.1016/j. ctcp.2019.02.006
Kuribayashi T. Elimination half-lives of interleukin-6 and cytokine-induced neutrophil chemoattractant-1 synthesized in response to inflammatory stimulation in rats. Lab Anim Res 2018: 34(2), 80-83. Available from: https://doi.org/10.5625/ lar.2018.34.2.80.
Vachon Presseau E, Martel MO, Roy M, Caron E, Albouy G, Marin MF, Plante I, Sullivan MJ, Lupien SJ, Rainville P. Acute stress contributes to individual differences in pain and pain related brain activity in healthy and chronic pain patients. J Neurosci 2013;33(16):6826–6833.
Iwabe T, Ozaki I, Hashizume A. The respiratory cycle modulates brain potentials, sympathetic activity , and subjective pain sensation induced by noxious stimulation. Neurosci Res 2014;84:47–59. Available from: http://dx.doi.org/10.1016/j.neures. 2014.03.003
Steinberg LJ, Rubin Falcone H, Galfalvy HC, Kaufman J, Miller JM, Sublette ME, Cooper TB, Min E, Keilp JG, Stanley BH, Oquenda MA, Ogden RT, Mann JJ. Cortisol stress response and in vivo pet imaging of human brain serotonin 1a receptor binding. Int J Neuropsychopharmacol 2019;22(5):329–338.
Badawy AA, Morgan CJ, Lovett JW, Bradley DM, Thomas R. Decrease in circulating tryptophan availability to the brain after acute ethanol consumption by normal volunteers: implications for alcohol-induced aggressive behaviour and depression. Pharmacopsychiatry 1995;28:93–97.
Úbeda D’Ocasar E, Jiménez Díaz Benito V, Gallego Sendarrubias GM, Valero Calero JA, Vicario Merino JA, Vicario Merino A, Hervás Pérez JP. Pain and cortisol in patients with fibromyalgia: systematic review and meta-analysis. Diagnostics (Basel) 2020;10(11):922. doi: 10.3390/diagnostics10110922.
Published
2021-06-10
How to Cite
Sandoval Valerio, A. K., Aguilera-Sosa, V. R., Miliar García, Ángel, Gómez López, M., García García, C., Leija Alva, G., Sánchez-Camacho, J. V., & Pérez-Vielma, N. M. (2021). Modulation of catastrophic thinking, pain and inflammation in fibromyalgia: from behavior to molecular biology.: Modulación del pensamiento catastrófico, dolor e inflamación en fibromialgia. Del comportamiento a la biología molecular. Investigación Clínica, 62(2), 140-158. https://doi.org/10.22209/IC.v62n2a05
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Original Works
