Effects of somatostatin in combination with early hemoperfusion on inflammatory, hemorheological and oxidative parameters during the treatment of acute pancreatitis.:

Hengyong  Zhai; Bin  Yang; Yiwei  Fu; Dongli  Zhang; Yujiang  Li; Junxing  Huang

doi:10.54817/IC.v64n1a04

Hengyong Zhai Department of Gastroenterology, Taizhou People’s Hospital, China. https://orcid.org/0000-0002-0015-9340
Bin Yang Department of Gastroenterology, Taizhou People’s Hospital, China. https://orcid.org/0000-0002-7647-9973
Yiwei Fu Department of Gastroenterology, Taizhou People’s Hospital, China. https://orcid.org/0000-0003-2799-5450
Dongli Zhang Department of Gastroenterology, Taizhou People’s Hospital, China. https://orcid.org/0000-0003-3031-2526
Yujiang Li Department of Gastroenterology, Taizhou People’s Hospital, China. https://orcid.org/0000-0001-9844-7043
Junxing Huang Department of Gastroenterology, Taizhou People’s Hospital, China. https://orcid.org/0000-0001-7199-4717

DOI: https://doi.org/10.54817/IC.v64n1a04

Keywords: somatostatin, hemoperfusion, acute pancreatitis, inflammatory response, stress response

Abstract

We aimed to evaluate the effects of somatostatin combined with early hemoperfusion on inflammatory and stress responses during acute pancreatitis (AP) treatment. A total of 159 AP patients treated from September 2016 to January 2020 were randomly divided into three groups A-C (n=53). In addition to routine treatment, groups A-C were additionally given somatostatin, early hemoperfusion, and somatostatin combined with early hemoperfusion, respectively. Their inflammatory factors, stress response, intestinal mucosal barrier, hemorheological indices, recovery time, length of stay, clinical efficacy, and adverse reactions were compared. The levels of serum interleukin-10 (IL-10), catalase and glutathione peroxidase rose in the three groups after ten days of treatment, compared with values before treatment, being the highest rise in group C. The levels of IL-18, tumor necrosis factor-α, soluble intercellular adhesion molecule-1, procalcitonin, high mobility group protein B1, lipid hydrogen peroxide, advanced oxidation protein products, epinephrine, cortisol, D-lactic acid, diamine oxidase, and endotoxin decreased after ten days of treatment compared with those before treatment, which were lowest in group C (P<0.05). After ten days of treatment, the levels of hemorheological indices were significantly lower than those before treatment (P<0.05). Compared with groups A and B, group C had a shorter recovery time of urine amylase, bowel sound and passing gas, remission time of abdominal pain, length of stay, and a higher total response rate (P<0.05). During AP treatment, somatostatin combined with early hemoperfusion effectively relieved inflammatory and stress responses, protected the intestinal mucosal barrier function and improved the hemorheology, thereby promoting the recovery and benefiting the prognosis of patients.

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Effects of somatostatin in combination with early hemoperfusion on inflammatory, hemorheological and oxidative parameters during the treatment of acute pancreatitis.

Efectos de la somatostatina en combinación con hemoperfusión precoz sobre parámetros inflamatorios, hemorreológicos y oxidativos durante el tratamiento de la pancreatitis aguda.

Abstract

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