Effect of vitamin D drops combined with conventional western medicine on children with Type 1 diabetes mellitus.
Efecto de gotas de vitamina D, combinadas con la medicina occidental convencional, en niños con diabetes mellitus Tipo 1.
Abstract
We investigated the therapeutic effect of vitamin D (VitD) drops, combined with conventional western medicine (insulin), on children with type 1 diabetes mellitus (T1DM). Eighty-four children with T1DM were divided into a routine group and an observation group (42 cases in each group). The routine group was treated with insulin; while the observation group was treated with insulin plus VitD drops. The serum levels of 25-hydroxyvitamin D3 (25(OH)D3) were compared between the two groups before and after treatment. The daily dosage of insulin, time needed for glucose control, two-hour postprandial blood sugar and frequency of episodes of hypoglycemia, were recorded. Flow cytometry was used to detect and compare interferongamma(INF-γ), interleukin 4(IL4),and INF-γ/IL -4 expression in CD4+ T cells of peripheral blood before and after treatment. Complication rates and readmission rates were documented dur-ing the six-month follow-ups. VitD drops significantly improved serum vitamin D levels in the routine group (P<0.05). Compared with this group, the daily doses of insulin were lower, the time of blood sugar reaching normal ranges was shorter and the frequency of hypoglycemia was lower in the observation group (P<0.05). There were significant differences in the 2-hour postprandial blood sugar levels, and flow cytometry results between the two groups (P<0.05). VitD drops combined with insulin are beneficial for blood glucose control of children with T1DM, effectively reducing the insulin utilization rate, reducing the fre-quency of hypoglycemia, and helping to regulate the Th1/Th2 balance disorder. Complementary treatment with this vitamin is safe and reliable, and can reduce the incidence of complications and readmission rates.
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References
Yan JH, Zhang Y, Zheng XY, Luo SH, Ai HY, Lü J, Qiu LL, Zhang XW, Yang DZ, Yao B, Weng JP. Insulin regimes and impact on glycemic control in patients with type 1 diabetes. Zong yi xue za zhi 2017;97(8):587- 591.
Wang T, Zhang J, Qi FF. Relationship between serum 25(OH)D3 level and islet β cell function in individuals with different glucose tolerance. Int J Endo Metabol 2016; 36(4):226-229.
Wierzbicka E, Szalecki M, Pludowski P, Jaworski M, Brzozowska A. Vitamin D status, body composition and glycemic control in Polish adolescents with type 1 diabetes. Minerva Endocrinol 2016; 41(4):445-455.
Wang XJ, Wang ZH, Dong YH. Comparisons of changes in BMI and waistheight ratio among Chinese Han students from 2010 to 2014. Chin J School Health 2017; 38(6):888-890.
Chinese Editorial Board of Guidelines for Diagnosis and Treatment of T1DM. Guidelines for Diagnosis and Treatment of T1DM. Beijing, People’s Publish House Co., Ltd 2013:13-15.
Censin JC, Nowak C, Cooper N, Bergsten P, Todd JA, Fall T. Childhood adiposity and risk of type 1 diabetes: a Mendelian randomization study. PLoS Med 2017; 14(8):100-110.
Luo SM, Ma XQ, Zhou ZG. The genetic characteristics of fulminant type 1 diabetes. Nat Med J Chin 2017; 97(8):561-563.
Wang XJ, Wang T, Yu M. Analysis of clinical characteristics in 12 patients with fulminant type 1 diabetes mellitus. Chin J Diabet 2018; 26(1):69-73.
Li Q, Yang Y, Liu BB. Effects of 1, 25 (OH) D on the content of TG in HepG2 cells and its mechanism. Chin J Diabet 2017; 25(11):57-61.
Wang KX, Zhang J, Ma DL. A Meta-analysis of correlation between vitamin D and diabetic foot. J Clinic Pathol Res 2017; 37(10):173-180.
Wu M, Lu JX, Huang Y. Analysis of the correlation between vitamin D and β-cell function in type 1 diabetic patients. Chin J Endocrinol Metabol 2013; 29(10):832-835.
Vaseghi H, Jadali Z. Th1/Th2 cytokines in Type 1 diabetes: Relation to duration of disease and gender. Ind J Endo Metab 2016; 20(3):312-316.
Bao R, Liu, X. Research progress of monocyte chemoattractant protein receptor. Chin Bult Life Sci 2006; 18(5): 477.
Kuwahara M, Ise W, Ochi M, Suzuki J, Kometani K, Maruyama S, Izumoto M, Matsumoto A, Takemori N, Takemori A, Shinoda K. Bach2-Batf interactions control Th2-type immune response by regulating the IL -4 amplification loop. Nat Commun 2016;7(7):125-130.
Bogdanou D, Penna-Martinez M, Filmann N, Chung TL Moran Y, Wehrle J, Baden-hoop K. T1lymphocyte and glycemic status after vitamin D treatment in type 1 diabetes: a randomized controlled trial with sequential crossover. Diabet Metabol Res Rev 2017; 33(3): e2865.
